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Indigo Root Home About Services Clinical Evidence Safety & Protocol Considerations Mechanisms & Pharmacology Contact Research & safety overview Ibogaine Hydrochloride A plainspoken guide to the purified salt form of ibogaine: what it is, where research stands, and why legal status and safety context matter. Review clinical evidence Consider safety context Compound snapshot C₂₀H₂₆N₂O Ibogaine hydrochloride is the stable, crystalline salt form commonly discussed in research and clinical handling contexts. Form Hydrochloride salt Status Not FDA-approved Origin Indole alkaloid associated with Tabernanthe iboga Research Investigated across addiction, trauma, and brain-injury contexts Risk Documented cardiovascular and interaction concerns require caution Definition & scope A standardized form, not a simple category. Ibogaine is a naturally occurring indole alkaloid associated with the root bark of Tabernanthe iboga . The broad ibogaine record includes its historical use and the later scientific attention to its psychoactive and pharmacological effects. Ibogaine hydrochloride, often called ibogaine HCl, is the pharmaceutical-grade crystalline salt form produced through extraction or semisynthesis and conversion to a hydrochloride salt. This form is used when stability and standardized dosing are central research or clinical concerns. Free base formula C₂₀H₂₆N₂O Typical research form Oral, encapsulated ibogaine HCl Pharmacology Multiple receptor and transporter targets United States status Schedule I; not FDA-approved Its pharmacology is polypharmacologic: ibogaine interacts with opioid receptors, dopamine and serotonin transporters, NMDA receptors, and nicotinic acetylcholine receptors, among other targets. A detailed peer-reviewed pharmacology review describes why that broad activity profile complicates simple claims about one mechanism or one outcome. Research workflow Three questions that keep the subject in focus. 01 / Form What is being studied? Separ

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